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Wounds due to radiation therapy

Radiation injury is the damage to the soft tissue and bone following radiation therapy.
There are early and late effects (occurs weeks and years after the radiation) caused by ischemia, interruption of the blood supply and direct cells damage, which are sensitive to radiation.

Soft tissue radiation injury:



Bone radiation injury:



Eye radiation injury:



Clinical application of HBO


References:

  1. Aanderud L, Thorsen E, Brattebo G, Forland M, Kristensen G: Hyperbaric oxygen treatment for radiation reactions. Tidsskr Nor Laegeforen; 30; 120(9):1020-2, Mar 2000
  2. Bem J, Bem S, Singh A:  Use of hyperbaric oxygen chamber in the management of radiation-related complications of the anorectal region: report of two cases and review of the literature.  Dis Colon Rectum; 43(10): 1435-8, Review, Oct 2000
  3. Bevers RFM, Bakker DJ, Kurth KH: Hyperbaric oxygen treatment for hemorrhagic radiation cystitis.  The Lancet; 346:803-805, 1995
  4. Borruat FX, Schatz NJ, Glaser JS, Feun LG, Matos L: Visual recovery from radiation-induced optic neuropathy. The role of hyperbaric oxygen therapy.  J Clin Neuroophthalmol;13 (2):98-101, Jun1993
  5. Cronje FJ: A review of the Marx protocols: Prevention and management of osteoradionecrosis by combining surgery and hyperbaric oxygen therapy.  SADJ; 53(10): 469-71, Review, Oct 1998
  6. Davis JC, Dunn JM, Gates GA, Heimbach RD:  Hyperbaric oxygen a new adjunct in the management of radiation necrosis. Arch Otolaryngol; 105 (2): 58-61, Feb 1979
  7. Del Pizzo JJ, Chew BH, Jacobs SC, Sklar GN; Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen: long-term followup. J Urol; 160 (3 Pt 1): 731-3, Sep1998
  8. Feldmeier JJ, Heimbach RD, Davolt DA, Court WS, Stegmann BJ, Sheffield PJ: Hyperbaric oxygen as an adjunctive treatment for delayed radiation injury of the chest wall: a retrospective review of twenty-three cases. Undersea Hyperb Med; 22(4): 383-93, Dec1995
  9. Feldmeier JJ,Newman R, Davolt DA, Heimbach RD, et al: Prophylactic hyperbaric oxygen for patient undergoing salvage  for recurrent  head and neck  cancers following full course irradiation.  Undersea Hyper Med; 25(suppl): 101, 998.
  10. Feldmeier JJ, Heimbach RD, Davolt DA, Stegmann BJ, Sheffield PJ: Hyperbaric oxygen as an adjunct of delayed radiation injuries of the extremities.  Undersea Hyper Med; 25(suppl): 9, 1998
  11. Feldmeier JJ, Heimbach RD, Davolt DA, Court WS, et al: Hyperbaric oxygen as adjunctive for delayed injuries of the abdomen and pelvis. Undersea Hyper Med; 23(4): 205-213, 1996
  12. Filntisis GA, Moon RE, Kraft KL, Farmer JC, Scher RL, Piantadosi CA: Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18 cases and review of the literature. Ann Otol Rhinol Laryngol; 109 (6):554-62, Jun 2000
  13. Ganstrom G, Jaccobson M, Tjellstrom A: Titanium implants in irradiated tissue: benefits from Hyperbaric oxygen. The International Journal of Oral& Maxillofacial Implants; 7(1): 15-25, 1992
  14. Ganstrom G, Tjellstrom A, Branermark P, et al: Bone-anchored reconstruction of the irradiated head and neck cancer patient.  Otolaryngology-Head and Neck Surgery; 108 (4):334-343, 1993
  15. Greenwood TW, Gilchrist AG: Hyperbaric oxygen and wound healing in post-irradiation head and neck surgery. Br J Surg; 50:394, 1973
  16. Hartmann KA, Almeling M, Carl UM, Schmitt G. Comment:  Hyperbaric oxygenation (HBO) in the treatment of radiogenic side effects. Clinical experiences are decisive! Strahlenther Onkol; 174 (4): 221-2, Apr 1998
  17. Hart GB, Strauss MB: Hyperbaric oxygen in the management of radiation injury. In Schmutz J. (ed): Proceedings of the First Swiss Symposium on Hyperbaric Medicine. Basel, Switzerland: Foundation for Hyperbaric Medicine ; pp. 31-51, 1986
  18. Hart GB, Mainous EG:  The treatment of radiation necrosis with hyperbaric oxygen Cancer; 37:2580-2585, 1976
  19. Jamil MU, Eckardt A, Franko W: Hyperbaric oxygen therapy. Clinical use in treatment of osteomyelitis, osteoradionecrosis and reconstructive surgery of the irradiated mandible. Mund Kiefer Gesichtschir; 4(5): 320-3, Sep 2000
  20. Kaufman T, Hirshowitz B, Monies-Chass I: Hyperbaric oxygen for postirradiation osteomyelitis of the chest wall. Harefuah 97:220-222, 271, 1979
  21. Kindwall E: Hyperbaric oxygen’s effect on radiation necrosis. Clinics in plastic surgery; 12 (3): 473-483, 1993
  22. London SD, Park SS, Gampper TJ, Hoard MA: Hyperbaric oxygen for the management of radionecrosis of bone and cartilage. Laryngoscope; 108(9): 1291-6, Sep 1998
  23. Maier A, Gaggl A, Klemen H, Santler G, Anegg U, Fell B, Karcher H, Smolle-Juttner FM, Friehs GB:  Review of severe osteoradionecrosis treated by surgery alone or surgery with postoperative hyperbaric oxygenation. Br J Oral Maxillofac Surg; 38(3): 173-6, Jun 2000
  24. Marx RE, Johnson RP, Kline SN:  Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assn; 111:49-54, 1985
  25. Marx RE, Ehler WJ, Tayapongsak P, et al; Relationship of oxygen dose to angiogenesis induction in irradiation tissue. The American Jurnal of Surgery; 160:519-524, 1990
  26. Marx RE: A new concept in treatment of osteoradionecrosis. Journal of Oral Maxillofacial Surgery; 41:351-357, 1983
  27. Mathews R, Rajan N, Josefson L, Camporesi E, Makhuli Z:  Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis.  J Urol; 161:435-437, 1999
  28. Peusch-Dreyer D, Dreyer KH, Muller CD, Carl U. Management of postoperative radiation injury of the urinary bladder by hyperbaric oxygen (HBO). Strahlenther Onkol; 174 Suppl 3:99-100, Nov 1998
  29. Plafki C, Carl UM, Glag M, Hartmann KA:  The treatment of late radiation effects with hyperbaric oxygenation (HBO). Strahlenther Onkol; 174 Suppl 3:66-8, Review, Nov 1998
  30. Pomeroy BD, Keim LW, Taylor RJ: Preoperative hyperbaric oxygen therapy for radiation induced injuries. J Urol; 159(5): 1630-2, May 1998
  31. Rijkmans BG, et al: Succesful treatment of radiation cystitis with hyperbaric oxygen Eur Urol; 16:354-356, 1989
  32. Roden D, Bosley TM, Fowble B, Clark J, Savino PJ, Sergott RC, Schatz NJ: Delayed radiation injury to the retrobulbar optic nerves and chiasm.  Clinical syndrome and treatment with hyperbaric oxygen and corticosteroids. Ophthalmology; 97(3): 346-51, Mar 1990
  33. Vudiniabola S, Pirone C, Williamson J, Goss AN:  Hyperbaric oxygen in the therapeutic management of osteoradionecrosis of the facial bones. Int J Oral Maxillofac Surg; 29(6): 435-8, Dec 2000
  34. Vudiniabola S, Pirone C, Williamson J, Goss AN:  Hyperbaric oxygen in the prevention of osteoradionecrosis of the jaws. Aust Dent J; 44(4): 243-7, Dec 1999
  35. Williams J, Clarke D, Dennis WA, et al: The treatment of pelvic soft tissue radiation necrosis with hyperbaric oxygen. Am J Obstet Gynecol; 167(2):412-416, 1992
  36. Weiss JP, Mattei DM, Neville EC, Hanno PM. Hyperbaric oxygen: Primary treatment of radiation-induced cystitis with hyperbaric oxygen: 10-year experience. J Urol; 151 (6): 1514-1517, 1994