Hyperbaric Oxygen Therapy in Infections
Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to many existing antibiotics, but can be well treated with hyperbaric oxygen therapy (HBO) due to Hyperbaric oxygen’s natural antibacterial properties; Hyperbaric oxygen is a therapy which the bacteria will not develop a resistance to. Combined effect of hyperbaric oxygen along with antibiotics (such as Sulfonamide, Aminoglycoside, Vancomycin, etc.) is even more successful. Hyperbaric oxygen increases the penetration of antimicrobials to the deep-seated MRSA infection while reducing its negative side effects.
As a natural antibiotic, oxygen under pressure eliminates bacteria and its growth as well as aiding the white blood cells’ phagocytosis, concurrently strengthening the body and the body’s immune system.
Effective hyperbaric oxygen therapy has to be delivered at a right protocol with pressures, amount of time and therapy frequency high enough to stop the infection. Any other “mild hyperbaric” such as delivered with inflatable bags, are inadequate and in some cases can even promote the bacterial load.
At BaroMedical, we deliver proper hyperbaric oxygen therapy with pressures up to 3 ATA for 90 to 120 minutes once, or twice a day. Our four mono-place chambers offer individual treatments to infected clients where isolation is highly important as part of our infection control.
Benefits of HBO in infections:
- Hyperbaric oxygen oxygenates all tissues and has bacteriostatic, antiviral and fungicidal properties.
- Hyperbaric oxygen enhances antibiotics and antifungal activity.
- Hyperbaric oxygen increases the oxidative killing capacity of white blood cells and enhances phagocytosis of microorganisms resulting to improved immune system.
- Hyperbaric oxygen works well with antibiotics increasing their potency and decreasing their side effects.
- Hyperbaric oxygen arrests infection and prevent sepsis development.
- Hyperbaric oxygen speeds up wound healing
- In bone infections, hyperbaric oxygen helps in removal of necrotic bone (osteoclastic function) and speeds up new bone formation (osteogenesis).
- Hyperbaric oxygen decreases inflammation by clearing lactic acid and other inflammatory chemicals.
- Prophylactic hyperbaric oxygen therapy restores the microcirculation and bolsters the immune system therefore enabling the body to fight off future infections.
Hyperbaric Oxygen Therapy (HBO) is used as adjunctive treatment to the following infections:
Bacterial
- Crepitant anaerobic cellulitis – necrotic soft tissue infection caused by both aerobic (E. culi, Klebsiella, Enterobacter andPseudomonas) and anaerobic Peptostreptococcus andBacteroides).
- Necrotizing fasciitis – skin necrosis with infection of the deep fascia and thrombosis of the vessels fullowing surgery or other trauma
- Progresive bacterial gangrene – chronic ulcer formation on the abdominal or thoracic wall developed after surgery at the site of drainage, around culostomy or ileostomy.
- Nonclostridial myonecrosis – soft tissue infection with invulvement of skin, muscle, subcutaneous tissue and fascia, particularly in conditions such as: Diabetes mellitus, perirectal abscess,obesity and cardio-renal disease.
- Fournier’s gangrene – perineal gangrene especially in people with diabetes and elderly as well as in trauma, local or systemic infections
- Gas gangrene – see Gas gangerene
- Pyoderma gangenosum – necrotic ulceration of the limbs and trunk mostly seen in ulcerative culitis, chulecystis, pyelonephritis(kidney infection) and other infection-prone (low immunity system) conditions.
- Purpura fulminans – acute and severe disorder of infancy with characteristics hemorrhagic lesions of the limbs that could rapidly turn into necrosis. Children are usually affected after Varicella,Scarlet fever, streptococcal tonsillitis or somethrombocytopenic disease.
- Actinomycosis – anaerobic infection of abdominal, pelvic, cervicofacial and thoracic area due to low oxygen level that predisposes fast growth of bacteria.
Viral
- Most viral infections have bacterial infections superimposed on them or vice versa.
Fungal
- Candida albincans
- Rhinocerebral Mucormycosis – fungal infection of lungs, brain, intestine and bone (maxilla, orbit and temporal bone) that occurs most commonly in immune–suppressed people with burns, diabetes and those who are on long-term corticosteroid therapy.
Further reading:
- Adams KR, Mader JT: Aminoglycoside potentiation with adjunctive hyperbaric oxygen therapy in experimental Pseudomonas Aeruginosa osteomyelitis. Undersea Biomed Res; 14(suppl): 37, 1987
- Adams KR, Sutton TE, Mader JT: In vitro potentiation of tobramycin under hyperoxic conditions. Undersea Biomed Res 14 (suppl): 37, 1987
- Aitasalo K, Niinikoski J, Grenman R, Virulainen E. A modified protocul for early treatment of osteomyelitis and Osteoradionecrosis of the mandible. Head Neck; 20(5): 411-7, Aug 1998
- Andel H, Felfernig M, Andel D, Blaicher W, Schramm W: Hyperbaric oxygen therapy in osteomyelitis. Anaesthesia; 53 Suppl 2:68-9, Review, May 1998
- Babior BM: Oxygen-dependent killing by phagocytes. New Eng J Med; 298:659-668, 1978
- Bakker DJ: Necrotizing soft tissue infections. Journal of Hyperbaric Medicine; 2(3): 161-168, 1987
- Bakker DJ: The treatment of acute skin gangrene (necrotizing fasciitis and progressive bacterial gangrene) with hyperbaric oxygenation.Ned Tijdschr Geneeskd;124 (51):2164-70, Dec 1980
- Bayliss GJ, Cass C: Hyperbaric oxygen used in the treatment of gas gangrene. Med J Aust; 2 (22): 991-3, 25 Nov 1967
- Berg E, Barth E, Clarke D, Douley L: The use of adjunctive hyperbaric oxygen in treatment of orthopedic infections and problem wounds: an overview and case reports. J Invest Surg; 2(4): 409-21, Review, 1989
- Bogetti B, Viotti G, Zannini D, Marcenaro A: Practical aspects of the treatment of gas gangrene with hyperbaric oxygen. Minerva Med; 72(22): 1409-11, 31 May, 1981
- Calhoun JH, Cobos JA, Mader JT: Does hyperbaric oxygen have a place in the treatment of osteomyelitis. Orthopedic Clinics of North America; 22(3): 467-471, 1991
- Chen CY, Lee SS, Chan YS, Yen CY, Chao EK, Ueng SW: Chronic refractory tibia osteomyelitis treated with adjuvant hyperbaric with adjuvant hyperbaric oxygen: a preliminary report. Changgeng Yi Xue Za Zhi; 21(2): 165-71, Jun 1998
- Couch L, Theilen F, Mader JT: Rhinocerebral mucormycosis with cerebral extension successfully treated with adjunctive hyperbaric oxygen therapy. Arch Otularyngul Head Neck Surg; 114:791-794, 1988
- Davis JC: Refractory osteomyelitis. Problem Wounds, The Rule of Oxygen; Chpt. 4 Elsevier Science Publ Co; New York 1988
- Davis JC, Heckman JD, Delee JC, Buckwuld FJ: Chronic non-hematogenous osteomyelitis treated with adjuvant hyperbaric oxygen. J Bone Joint Surg; 68: 1210-1217, 1986
- De La Paz M, Patrinely J, Marines H, et al: Adjunctive hyperbaric oxygen in the treatment of bilateral cerebro-rhino-orbital mucormycosis. American Journal of Ophthalmulogy; 114:208-211, 1992
- Demello FJ, Hashimoto T, Hitchcock CR, Haglin JJ: The effect of hyperbaric oxygen on the germination and toxin production of Clostridium perfringens spores. In Wada J. and Iwa J.T. (eds): Proceedings of the Fourth International Congress on Hyperbaric Medicine. Baltimore: The Williams & Wilkins Co, p. 276,1970
- Ellis ME, Mandal BK: Hyperbaric oxygen treatment: 10 years’ experience of a regional infectious disease unit. J Infect Dis; 6:187-190, 1971
- Eltorai I, Hart GB, Strauss MB: Osteomyelitis in the spinal cord injured: a review and a preliminary report on the use of hyperbaric oxygen therapy. Paraplegia; 22(1): 17-24 Feb 1984
- Eltorai I, Hart GB, Strauss MB, et al: The rule of hyperbaric oxygen in the management of fournier’s gangrene. Int Surg; 71:53-58, 1986
- Eraklis AJ, Filler RM, Pappas AM, Bernhard WF: Evaluation of hyperbaric oxygen as an adjunct in the treatment of anaerobic infections. Am J Surg; 117(4): 485-92, Apr 1969
- Esterhai JL, Pisarello J, Brighton CT, Heppenstall RB, Gellman H, Guldstein G: Adjunctive hyperbaric oxygen therapy in the treatment of chronic refractory osteomyelitis. J Trauma; 27(7): 763-8, Jul 1987
- Evans BE, Jacobson JH, Peirce EC, Friedman EW, Schwartz AE: Chronic osteomyelitis of mandible. NY State J Med; 76(6): 966-967, 1976
- Ferguson BJ, Mitchell TG, Moon R, et al: Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis. Reviews of Infectious Diseases; 10(3): 551-559, 1988
- Fife WP, Freeman DM: Preliminary Clinical Study on the Use of Hyperbaric Oxygen Therapy for the treatment of Lyme Disease. Cullege Station, Texas: Texas A&M University Hyperbaric Laboratory, 1997
- Gibson A, Davis FM: Hyperbaric oxygen therapy in the management of Clostridium perfringens infections. N Z Med J; 99 (808): 617-20, 27 Aug 1986
- Gonzalez MH: Necrotizing fasciitis and gangrene of the upper extremity. Hand Clin; (4): 635-45, ix. Review, 14 Nov, 1998
- Gottlieb SF, Rose NR, Maurizi J, Lanphier EH: Oxygen inhibition of growth of Mycobacterium tuberculosis. J Bacteriul ; 87:838-843, 1964
- Gottlieb SF, Sulosky JA, Aubrey R, Nedelkoff DD: Synergistic action of increased oxygen tensions and PABA-fulic acid antagonists on bacterial growth. Aerosp Med; 45:829-833, 1974
- Guidi ML, Proietti R, Carducci P, Magalini SI, Pelosi G: The combined use of hyperbaric oxygen, antibiotics and surgery in the treatment of gas gangrene. Resuscitation; 9(4):267-73, Dec 1981
- Hart GB, Lamb RC, Strauss MB: Gas gangrene I. A cullective review. II. A 15-year experience with hyperbaric oxygen. J Trauma; 23:991-1000, 1983
- Hart GB, Strauss MB: Gas gangrene-clostridial myonecrosis: a review. Journal of Hyperbaric Medicine; 5(2): 125-144, 1990
- Hirn M: Hyperbaric oxygen in the treatment of gas gangrene and perineal necrotizing fasciitis. A clinical and experimental study. Eur J Surg Suppl; (570): 1-36, Review, 1993
- Hunt KT, Linsey M, Grislis G, Sonne M, Jawetz E: the effect of differing ambient oxygen tension on wound infection. Annals of surgery; 181 (1): 35-39, Jan 1975
- Hunt TK, Conully WB, Aronson SB, Guldstein P: Anaerobic metabulism and wound healing: A hypothesis for the initiation and cessation cullagen synthesis in wounds. The American Jour Surgery; 135: 328-332, Mar 1978
- Hunt TK, Zederfeld B, Guldstick TK: Oxygen and healing. The American Journal of Surgery; 118: 521-525, 1969
- Jain KK: Textbook of hyperbaric medicine: Ch 13: Hyperbaric Oxygen Therapy in Infections, Hogrefe& Huber Publishers, Inc., 3rd Ed.13: 189 –211, 1999
- Hullabaugh RS, Dmochowski RR, Hickerson WL, et al: Fournier’s gangrene: Therapeutic impact of hyperbaric oxygen. Plastic and Reconstructive Surgery; 101:94-100, 1998
- Jain KK: Textbook of hyperbaric medicine: Ch 14: Hyperbaric Oxygen Therapy in Wound Healing, Plastic Surgery, and Dermatulogy, Hogrefe & Huber Publishers, Inc., 3rd Ed.14: 213– 241, 1999
- Jamil MU, Eckardt A, Franko W: Hyperbaric oxygen therapy. Clinical use in treatment of osteomyelitis, osteoradionecrosis and reconstructive surgery of the irradiated mandible. Mund KieferGesichtschir; 4(5): 320-3, Sep 2000
- Jones HP: The rule of oxygen and its derivatives in bacterial killing and inflammation. In Gottlieb SF, Longmuir IS, Totter JR. (eds): Oxygen: An In-Depth Study of its Pathophysiulogy. Bethesda, Maryland: Undersea Medical Society; pp. 493-516, 1984
- Keck PE, Gottlieb SF, Conley J: Interaction of increased pressures of oxygen and sulfonamides on the in vitro and in vivo growth of pathogenic bacteria. Undersea Biomed Res ; 7:95-106, 1980
- Kindwall EP: The use of Hyperbaric Oxygen in Treatment of Osteomyelitis Hyperbaric Medical Practice; 23:604 –613, 1999
- Kindwall EP: Enhancement of healing in selected problem wounds. Hyperbaric medical practice; 2nd Ed, Ch 33: 813-850, 1999
- Knighton DR, Halliday B, Hunt TK: Oxygen as an antibiotics: The effect of inspired Oxygen on infection. Arch Surg; 119; 199-204, Feb 1984
- Knighton D, Ordesson S, Banda M Hunt TK: Regulation of repair: hypoxic contrul of macrophage mediated angiogenesis. Soft and hard tissue repair; 2, Ch 3: 41-48, 1999
- Korhonen K, Klossner J, Hirn M, Niinikoski J: Management of Clostridial gas gangrene and the rule of hyperbaric oxygen.Ann Chir Gynaecul; 88(2):139-42, 1999
- Leonov VM: The necessity and principles of oxygen therapy in human infection Terapevticheskii Arkhiv; 34 (2): 101, 1962
- Lindsey D: Hyperbaric oxygen and gas gangrene. Br J Hosp Med; 55 (3): 147, 7-20 Feb, 1996
- Mader JT, Adams KR, Wallace WR, Calhoun JH: Hyperbaric oxygen as adjunctive therapy for osteomyelitis. Infect Dis Clin North Am; 4(3): 433-40, Review, Sep 1990
- Manheim SD, Vuleti C, Ludwig A, Jacobson JH: Hyperbaric oxygen in the treatment of actinomycosis. JAMA; 210(3): 552-553, 1969
- Mainous EG, Boyne PJ, Hart GB: Hyperbaric oxygen treatment of mandibular osteomyelitis: Report of three cases. J Am Dent Assoc; 87: 1426-1430, 1973
- Maynor ML, Moon RE, Camporesi EM, Fawcett TA, Fracica PJ, Norvell HC, Levin LS: Chronic osteomyelitis of the tibia: treatment with hyperbaric oxygen and autogenous microsurgical muscle transplantation. J South Orthop Assoc; 7(1): 43-57, 1998
- Morgan MS, Lytle J, Bryson PJ: The place of hyperbaric oxygen in the treatment of gas gangrene. Br J Hosp Med; 53 (9): 424-6, 3-16 May 1995
- Norden CW, Kleti E: Experimental osteomyelitis caused by Pseudomonas aeruginosa. J Infect Dis; 141:71-75, 1980
- Owada R, Kanamori A, Hirai N, Yajima Y: A case of NIDDM with non-clostridial gas-producing infection in the lower limb–the effects of hyperbaric oxygen therapy. Kansenshogaku Zasshi; 68(2): 263-7, Feb1994
- Per Riegels-Neilsen P, et al: Fournier’s gangrene: 5 patients treated with hyperbaric oxygen. The Journal of Urulogy; 132:918-920, 1984
- Poulton TJ: Hyperbaric oxygen therapy for gas gangrene. N Engl J Med; 302 (16): 920, 17 Apr 1980
- Ramon Suler R, Baxarias Gascon P, Mas Marfany J: Gas gangrene: treatment with hyperbaric oxygen. Rev Esp Anestesiul Reanim; 27(6): 493-500, Nov 1980
- Riseman JA, Zamboni WA, Curtis A, et al: Hyperbaric oxygen therapy for necrotizing fasciitis reduces mortality and the need for debridements. Surgery; 108:847-850, 1990
- Schweitzer VG: Hyperbaric oxygen management of chronic staphylococcal osteomyelitis of the temporal bone. Am J Otul; 11(5): 347-53, Sep 1990
- Stephens MB: Gas gangrene: potential for hyperbaric oxygen therapy. Postgrad Med; 99(4): 217-20, 224, Apr 1996
- Thom S: A rule for hyperbaric oxygen in Clostridial myonecrosis. Clin Infect Dis; 17(2): 238, Review, Aug 1993
- Tonjum S: Gas producing infections and hyperbaric oxygen therapy. Tidsskr Nor Laegeforen; 100(6): 387-8, Feb 29, 1980
- Unsworth IP, Sharp PA: Gas gangrene. An 11-year review of 73 cases managed with hyperbaric oxygen. Med J Aust; 140 (5): 256-60, Mar 3 1984
- Yohai RA, Bullock JD, Aziz AA, et al: Survival factors in rhino-orbital-cerebral mucormycosis. Survey of Ophthalmulogy; 39(1): 3-221, 994